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OM System

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

Micro Four Thirds Mount

Updated 200–800mm-equiv. telephoto with 5-axis Sync IS, improved AF, and 1125g body.

$1,499

Launch price

Released Sep 2024

vs

OM System

M.Zuiko Digital ED 12-40mm F2.8 PRO II

Micro Four Thirds Mount

IP53 weather-sealed standard zoom with constant F2.8, MSC autofocus, and 0.3× magnification at 40mm.

$1,299

Launch price

Released Feb 2022

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II is 2.6 years newer.

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Wins

1categories

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

WildlifeVideo & Hybrid

Wins

7categories

M.Zuiko Digital ED 12-40mm F2.8 PRO II

LandscapeTravel

Which would you choose?

TL;DR — Key differences

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II wins 1 categories·M.Zuiko Digital ED 12-40mm F2.8 PRO II wins 4 categories
  • AM.Zuiko Digital ED 100-400mm F5.0-6.3 IS II has higher OIS effectiveness (5 stops vs 0 stops)
  • BM.Zuiko Digital ED 12-40mm F2.8 PRO II has lower Min focus distance (20 cm vs 130 cm)
  • BM.Zuiko Digital ED 12-40mm F2.8 PRO II has lower Weight (382 g vs 1125 g)
  • BM.Zuiko Digital ED 12-40mm F2.8 PRO II has lower Length (84 mm vs 205.6 mm)
  • BM.Zuiko Digital ED 12-40mm F2.8 PRO II has lower Max aperture (Tele) (f/2.8 vs f/6.3)

Key specs at a glance

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS IIM.Zuiko Digital ED 12-40mm F2.8 PRO II
Focal Length100-400 mm12-40 mm
Max Aperturef/5-6.3f/2.8
MountMicro Four ThirdsMicro Four Thirds
CoverageMicro Four ThirdsMicro Four Thirds
Stabilization5 stopsNo
Weight1125 g382 g
Min Focus130 cm20 cm
Filter Size72 mm62 mm

Size and weight, to scale

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

86 × 206 mm

1125 g (2.48 lb / 39.68 oz)

Credit card shown to scale as a size reference (ISO 7810, 85.6 × 54 mm)

Credit card

85.6 × 54 mm

for scale

M.Zuiko Digital ED 12-40mm F2.8 PRO II

70 × 84 mm

382 g (0.84 lb / 13.47 oz)

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II is 122mm longer and 17mm wider than M.Zuiko Digital ED 12-40mm F2.8 PRO II.

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II is 743 g heavier than M.Zuiko Digital ED 12-40mm F2.8 PRO II.

Diameter (⌀) is the maximum barrel width; length is measured from the mount to the front of the lens.

Use-case scoring

Which one for what?

Algorithmic scores from verified specs · 10 = best in class

Use caseM.Zuiko Digital ED 100-400mm F5.0-6.3 IS IIM.Zuiko Digital ED 12-40mm F2.8 PRO II
Portrait
5.5Fair
3.0Limited
Sports & Action
6.5Good
4.5Fair
Video & Hybrid
7.0Good
5.0Fair
Landscape
4.0Fair
10.0Excellent
Travel
5.0Fair
7.0Good
Wildlife
9.5Excellent
2.0Limited
Macro & Close-up
3.5Limited
4.5Fair

Why pick one over the other

Reasons to choose the M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

  • OIS effectiveness

    5 stops vs 0 stops — higher is better

  • Special elements

    Adds 4 ED, 2 Super HR

  • Optical stabilization

    Only M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II supports it

Reasons to choose the M.Zuiko Digital ED 12-40mm F2.8 PRO II

  • Min focus distance

    20 cm vs 130 cm — lower is better

  • Special elements

    Adds 1 EDA, 2 Aspherical, 1 DSA…

  • Weight

    382 g vs 1125 g — lower is better

  • Length

    84 mm vs 205.6 mm — lower is better

  • Max aperture (Tele)

    f/2.8 vs f/6.3 — lower is better

  • Max aperture (Wide)

    f/2.8 vs f/5 — lower is better

  • Diameter

    69.9 mm vs 86.4 mm — lower is better

  • Max magnification

    0.3 × vs 0.29 × — higher is better

Shared specifications

Internal focus

Both support internal focus

Weather sealing

Both support weather sealing

Control ring

Both support control ring

Custom function button

Both support custom function button

Pros & cons at a glance

Editorially curated highlights and trade-offs.

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

Pros

  • Versatile zoom range covers multiple focal lengths in one lens
  • Built-in optical image stabilization
  • Weather-sealed construction for outdoor shooting

Cons

  • Relatively heavy for extended handheld use
  • Slower maximum aperture limits low-light performance

M.Zuiko Digital ED 12-40mm F2.8 PRO II

Pros

  • Constant F2.8 across 12–40mm (24–80mm equiv.)
  • IP53 dust/splash/freeze resistance with ZERO coating
  • Compact 382g body with MF clutch and L-Fn button

Cons

  • No lens-based IS — relies on Sync IS in compatible bodies
  • Extending barrel design

Decided which one is right for you?

Compare live prices for the M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II and M.Zuiko Digital ED 12-40mm F2.8 PRO II at major authorized retailers.

OM System M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II

OM System M.Zuiko Digital ED 12-40mm F2.8 PRO II

Affiliate disclosure: As an Amazon Associate, Cameraegg earns from qualifying purchases. Cameraegg may also earn commission from B&H links, at no extra cost to you.

Full specifications

= category winner

M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II
M.Zuiko Digital ED 12-40mm F2.8 PRO II
Focal length (Min)
100 mm
12 mm
Focal length (Max)
400 mm
40 mm
Max aperture (Wide)
f/5
f/2.8+1.7 stops wider
Max aperture (Tele)
f/6.3
f/2.8+2.3 stops wider
Elements
21
14
Groups
14
9
Special elements
4 ED, 2 Super HR, 2 HR
1 EDA, 2 Aspherical, 1 DSA, 2 ED, 1 HD, 2 HR
M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II
M.Zuiko Digital ED 12-40mm F2.8 PRO II
Min focus distance
130 cm
20 cm−110 cm less
Max magnification
0.29 ×
0.3 ×+3%
Autofocus motor
Dual linear motors
MSC (stepping motor)
Internal focus
Yes
Yes
M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II
M.Zuiko Digital ED 12-40mm F2.8 PRO II
Optical stabilization
Yes
No
OIS effectiveness
5 stops
0 stops
M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II
M.Zuiko Digital ED 12-40mm F2.8 PRO II
Weight
1125 g
382 g−743 g less
Length
205.6 mm
84 mm−122 mm less
Diameter
86.4 mm
69.9 mm−17 mm less
Filter thread size
72 mm
62 mm
Weather sealing
Yes
Yes
Diaphragm blades
9
7
M.Zuiko Digital ED 100-400mm F5.0-6.3 IS II
M.Zuiko Digital ED 12-40mm F2.8 PRO II
Lens mount
Micro Four Thirds
Micro Four Thirds
Format coverage
Micro Four Thirds
Micro Four Thirds

Specs sourced from manufacturer data. Use-case scores algorithmically derived. Last reviewed June 2026.